チアノーゼ性心疾患術後の女性の妊娠Pregnancy in Women after Surgery for Cyanotic Heart Disease
国立循環器病研究センター 産婦人科Department of Obstetrics and Gynecology, National Cerebral and Cardiovascular Center ◇ Osaka, Japan
長期予後の向上を背景に,先天性心疾患を持つ女性の多くが生殖年齢に達し,妊娠を希望するようになった.そのなかには,チアノーゼ性心疾患に対する修復術後や姑息術後の女性も含まれる.周産期の母体循環動態の変化は大きく,心不全や不整脈などの心血管合併症リスクが増大するが,チアノーゼ性心疾患術後の女性では,その傾向が顕著である.チアノーゼ性心疾患術後の女性においては,原疾患や手術術式,遺残病変や併存症の有無など,その病態が多岐にわたる.妊娠分娩時の母児リスクを軽減するためには,個々の病態に応じたテーラーメードな周産期医療が必要である.さらに,女性を取り巻くライフスタイルの変化から,妊婦の高齢化が進み,産科合併症のリスクにもより多くの配慮が必要である.ハイリスク例においては,プレコンセプションカウンセリングの実施と,専門的チーム医療による周産期管理が必須である.
Due to improved long-term prognosis for patients with congenital heart disease (CHD), more women with CHD, including those who have undergone surgical repair or palliation for cyanotic heart disease, reach reproductive age and wish to become pregnant. Such women have a high risk of perinatal cardiovascular events, including heart failure and arrhythmia, because of the substantial changes in maternal hemodynamics. This trend is particularly pronounced in women with cyanotic heart disease, even after surgery, and there is a wide range of pathological factors that must be considered, including the underlying disease, surgical technique, presence or absence of residual lesions, and comorbidities. Therefore, to reduce the risk to mother and child, perinatal medical care tailored to each woman’s condition and severity is necessary. Furthermore, changes in women’s lifestyles have led to advanced maternal age, so the risk of obstetric complications requires greater consideration. Preconception counseling and perinatal management by a specialized medical care team are essential in high-risk cases.
Key words: cyanotic heart disease; pregnancy; Fontan circulation; heart failure; arrhythmia
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