Online ISSN: 2187-2988 Print ISSN: 0911-1794
特定非営利活動法人日本小児循環器学会 Japanese Society of Pediatric Cardiology and Cardiac Surgery
Pediatric Cardiology and Cardiac Surgery 37(1): 10-17 (2021)


ダイレクトリプログラミングによる心血管発生と再生医学への新しい展開Direct Reprogramming as a Novel Approach for Cardiovascular Regeneration

1筑波大学医学医療系トランスボーダー医学研究センター再生医学分野Division of Regenerative Medicine, Transborder Medical Research Center (TMRC), Faculty of Medicine, University of Tsukuba ◇ Ibaraki, Japan

2筑波大学医学医療系循環器内科Department of Cardiology, Faculty of Medicine, University of Tsukuba ◇ Ibaraki, Japan

発行日:2021年4月1日Published: April 1, 2021


Direct cellular reprogramming provides a new strategy for tissue regeneration, especially to the adult heart. However, endogenous cardiomyocytes have limited regenerative capacity. Since our first report of direct cardiac reprogramming from cardiac fibroblasts with three cardiac developmental transcriptional factors (Gata4, Mef2c, and Tbx5), numerous international studies have been reported to reveal the molecular mechanisms of cardiac reprogramming and improve the efficiency of this nascent technology for cardiac regenerative medicine. These advancements include additional transcriptional factors, microRNAs, epigenetic factors, secreted factors, and cellular microenvironment. Cardiac reprogramming of human fibroblasts has also improved. Although direct cardiac reprogramming may resolve the difficulties in applying induced pluripotent stem cells for cardiac regeneration, numerous challenges remain for future clinical application. In this review, we will provide an update on recent advances in research on direct cardiac reprogramming and discuss the perspectives and challenges of this technology in clinical applications.

Key words: direct reprogramming; cardiac regeneration; transdifferentiation; cardiomyocytes

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