Online ISSN: 2187-2988 Print ISSN: 0911-1794
特定非営利活動法人日本小児循環器学会 Japanese Society of Pediatric Cardiology and Cardiac Surgery
Pediatric Cardiology and Cardiac Surgery 31(3): 88-94 (2015)


細胞シート工学による補助ポンプ型立体心筋組織の創生Development of Cardiac Tissues with the Ability for Independent Cardiac Assistance Using Cell Sheet Based Tissue Engineering

東京女子医科大学先端生命医科学センター先端生命医科学研究所Institute of Advanced Biomedical Engineering and Science, Center for Advanced Biomedical Sciences, Tokyo Women's Medical University ◇ 〒162-8480 東京都新宿区若松町2番2号2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan

受付日:2014年10月29日Received: October 29, 2014
受理日:2015年3月25日Accepted: March 25, 2015
発行日:2015年5月1日Published: May 1, 2015


For severe heart failure because of congenital heart disease, coronary artery disease, and dilated cardiomyopathy, heart transplantation is the definitive treatment approach for patients. However, a lack of donor organs remains a longstanding and serious problem worldwide. Artificial hearts, such as left ventricular assist devices, present problems related to thromboembolism, infection, gastrointestinal bleeding, and finite durability. Direct injection of isolated skeletal myoblasts and bone marrow-derived cells or cardiac stem cells has already been used clinically as a method to improve heart function by regenerating the myocardium and blood vessels. However, direct injection of the dissociated cells has shown to be slightly effective, and it is often difficult to control the form, dimensions or position of implanted cells. In an attempt to solve these problems, research has been initiated on reconstructing functional three-dimensional cardiac grafts using tissue engineering methods as a treatment for the next generation. Cell sheet transplantation has already been shown to be able to cure damaged hearts. In addition to cardiac patches transplanted directly onto damaged hearts, the next challenge is to fabricate organ-like tissues, such as tubular or spherical structures that are able to function as a cardiac pump with the potential for circulatory support.

Key words: regenerative medicine; heart failure; tissue engineering; cell sheet

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