Online ISSN: 2187-2988 Print ISSN: 0911-1794
特定非営利活動法人日本小児循環器学会 Japanese Society of Pediatric Cardiology and Cardiac Surgery
Pediatric Cardiology and Cardiac Surgery 40(1): 9-16 (2024)


川崎病血管炎と遠隔期血管リモデリングを考えるAre Patients After Kawasaki Disease at Increased Risk for Accelerated Vascular Remodeling?

北里大学医学部小児科学Department of Pediatrics, Kitasato University School of Medicine ◇ Kanagawa, Japan

発行日:2024年2月29日Published: February 29, 2024

川崎病は小児期に好発する急性全身性血管炎症候群であるが,冠動脈合併症以外の全身性血管炎の長期遠隔期の影響については不明な点が多い.はたして川崎病の既往は,将来的な動脈硬化など血管合併症のリスク因子になるのだろうか? 残念ながらこの問いに答えられる十分なエビデンスは存在しない.しかし筆者は,自身がこれまでに行ってきた血管と炎症に関する研究の経験をもとに,これまでに川崎病血管炎に関連して蓄積された研究成果の意義と研究手法の限界について検討し,次世代の研究者へ少しでも新たな視座を与えられるように願って解説を試みた.

Kawasaki disease is an acute systemic vasculitis syndrome that primarily affects childdren, but the long-term remote effects of systemic vasculitis beyond coronary complications are unknown. Is a history of Kawasaki disease a true risk factor for future vascular complications like atherosclerosis? Unfortunately, there is insufficient evidence to answer this question. However, based on my own experience in blood vessel and inflammation research, I attempted to review the significance of the research results findings to date on Kawasaki disease vasculitis, as well as the limitations of research methods, in the hope of providing new perspectives for the next generation of researchers.

Key words: Kawasaki disease; vasculitis; vascular remodeling; vascular stiffness; atherosclerosis

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