日本小児循環器学会雑誌 Pediatric Cardiology and Cardiac Surgery

Online ISSN: 2187-2988 Print ISSN: 0911-1794
特定非営利活動法人日本小児循環器学会 Japanese Society of Pediatric Cardiology and Cardiac Surgery
〒162-0801東京都新宿区山吹町358-5アカデミーセンター Japanese Society of Pediatric Cardiology and Cardiac Surgery Academy Center, 358-5 Yamabuki-cho, Shinju-ku, Tokyo 162-0801, Japan
Pediatric Cardiology and Cardiac Surgery 32(5): 397-408 (2016)
doi:10.9794/jspccs.32.397

ReviewReview

幹細胞からの心筋細胞分化,その機能解析と利用の展望Functional Assays and Future Perspectives in Derivation of Cardiomyocytes from Stem Cells

京都大学大学院医学研究科発生発達医学講座発達小児科学Department of Pediatrics, Graduate School of Medicine, Kyoto University ◇ Kyoto, Japan

発行日:2016年9月1日Published: September 1, 2016
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心臓内の心筋細胞のほとんどは最終分化した成熟細胞であり,それゆえ心不全患者に対する幹細胞由来分化心筋の臨床利用が長年望まれてきた.純粋な心筋幹細胞の同定は未だ困難で,同定できたとしても有効な移植方法についても模索中である.今回,その幹細胞からの心筋細胞分化,またその機能解析方法や利用の展望について総論的に述べる.

Cardiomyocytes are terminal differentiated and thus, once damaged, cannot be substantially replaced by proliferation of surrounding cells. Stem cell therapy, i.e., replacement therapy, has long been viewed as a new and effective approach for treatment of myocardial infarction and severe heart failure; however, clinical establishment of stem cell therapy has presented significant challenges due to the difficulties in efficient isolation and transplantation of cardiac-committed stem cells. This review summarizes the history, current overview, and future perspectives in cardiac stem cell research.

Key words: cardiomyocyte; functional analysis; stem cell; transplantation

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